Scop191 |link| Jun 2026

SCOP (Structural Classification of Proteins) was created to address this need. Developed initially by Alexey G. Murzin, Steven E. Brenner, Tim Hubbard, and Cyrus Chothia at the MRC Laboratory of Molecular Biology, SCOP offers a manual (and later semi-automated) classification of protein structural domains. The database provides a detailed description of the structural and evolutionary relationships of all proteins whose structure is known.

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While the original SCOP database was manually curated, the volume of new structures has accelerated. This led to the development of (SCOP Evolutionary Classification), which automates classification while maintaining the manual hierarchy standards. SCOP (Structural Classification of Proteins) was created to

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