As Sasuke runs out of chakra, Orochimaru attempts to take over his body using the Eight Branches Technique . Itachi uses the Sword of Totsuka to seal Orochimaru away forever, finally freeing Sasuke from the Cursed Seal.
Weakened by a terminal illness and the strain of his eyes, Itachi corners a terrified Sasuke. Instead of taking Sasuke's eyes as he had claimed he would, he smiles and pokes Sasuke's forehead—a gesture of affection from their childhood—before collapsing.
But for the original, canonical death of Itachi Uchiha in the living timeline: . in which episode does itachi die
Itachi’s death is revisited and given deeper emotional impact in ( Naruto Shippuden ) when the truth about the Uchiha Clan Massacre is fully revealed. Additionally, Itachi is later reanimated during the Fourth Great Ninja War (first appears in Episode 321) and finally meets his second end in Episode 358 ( "The End of the War" or similar titles depending on the arc), where his soul returns to the afterlife.
" (or "I Will Love You Forever"), Itachi's soul begins to fade back to the afterlife. Before disappearing, he uses his Sharingan to show Sasuke his memories of the Uchiha massacre, finally revealing the full truth. As Sasuke runs out of chakra, Orochimaru attempts
: The " Itachi Shinden " filler arc, which provides deep backstory on his childhood and his reasons for the massacre.
He leaves Sasuke with the parting message: "No matter what you decide to do from now on, I will love you always" . Instead of taking Sasuke's eyes as he had
Here’s a helpful write-up for anyone searching for when Itachi Uchiha dies in Naruto Shippuden :
Would you like a quick episode list for the entire Itachi vs. Sasuke fight as well?
Watch the climactic and emotional moments of Itachi's final confrontation with Sasuke: