by B.K. Roy is a foundational textbook widely recognized in the veterinary field for its comprehensive and accessible approach to drug science and toxicological principles. Published by Kalyani Publishers , the book serves as a critical resource for undergraduate students and practicing veterinarians alike. Core Content and Structure
| Sub‑topic | Key Concepts | |-----------|--------------| | | Agonist, partial agonist, antagonist, inverse agonist. | | Dose‑Response Relationships | • Graded (continuous) vs. Quantal (all‑or‑none). • EC₅₀ , ED₅₀ , LD₅₀ , Therapeutic Index (TI) . | | Mechanisms of Action | • Enzyme inhibition/activation. • Ion‑channel modulation. • Hormone receptor agonism/antagonism. • Signal‑transduction interference. | | Tolerance, Dependence & Addiction | • Pharmacokinetic tolerance (enhanced clearance) vs. pharmacodynamic tolerance (receptor down‑regulation). | | Drug Interactions | • Synergism , antagonism , potentiation . • Enzyme induction/inhibition (CYP450). | | Adverse Drug Reactions (ADRs) | • Type A (dose‑related, predictable) vs. Type B (idiosyncratic). | veterinary pharmacology and toxicology by bk roy pdf